Does 24 hours delay in oocyte retrieval can help gathering more mature oocytes? Acomparisition between two parameters : Day of oocyte retrieval and follicular size
Backgraound: one of the concern in assisted reproduction technology is achiving the best day for oocyte retrieval so that we get the highest amounts of mature oocyts.
Objective: The purpose of this study was to compare the effect of Day of oocyte retrieval and follicular size on oocyte maturation and fertilization rates.
Materials and Methods: This retrospective study was performed in Novin infertility treatment center from Oct 2016 to Jun 2018. All patient candidate for assisted reproduction technology underwent controlled ovarian hyperstimulation by antagonist protocol. The participants randomizations were done and patients were divided in to two groups.
In the first group, in the 9th day of cycle when at least 3 follicles with ≥ 18 diameter were seen by vaginal ultrasonography; final oocyte maturation was done by human choronic gonadotropin at the same day, but the second group in spite of at least 3 follicles with ≥ 18 diameter were seen but for the more chance of formation of more mature oocyte the HCG injection were done by 24 hours delayed.
Results: The variables such as prior IVF cycle, male factor, tubal factor, etc. were the same in the women surveyed. The age, BMI and AMH ranges were not significantly different between the two groups. The results showed that the number of oocyte maturation and oocyte quality in first group who retrieval based on follicular size were higher than the second group who retrieval the oocyte in 12th day of cycle. But there weren’t statistically diferent between two groups.
Conclusion: Delaying of triggering oocyte maturation by 24 hr in antagonist protocol have not beneficial nor harmful effect on the number of mature oocytes (MII) and oocyte quality.