Evaluation of gonadotropin dose on embryo aneuploidy rates
background: Ovarian stimulation regimens for in vitro fertilization seem to have a deleterious effect on oocyte quality and embryo aneuploidy in a dose-dependent manner. This study aims to test the influence of gonadotrophin doses on embryo aneuploidy rates.
methods: In this retrospective study, 32 patients were examined. Patients were divided into three groups based on the total dose of received gonadotropin ( group A≤ ۲۰۰۰ IU, ۲۰۰۰ IU < group B<2500 IU and group C ≥۲۵۰۰ IU). aneuploidy for chromosomes 5, 13 18, 21, X and Y were the main outcomes of the study.
results: There was no significant difference between group A and group B in aneuploidy rate. In those patients who placed in group A and B, significant increases in rates of chromosomally normal blastocysts were observed . In the group C, the aneuploidy rate increased significantly.
conclusions: Despite the limited numbers in our study, we can conclude that a decrease in the gonadotrophin dose could improve fertilization rates and embryo quality. However, due to the reduced oocyte numbers with lower doses, a similar reproductive outcome in terms of live births would be expected.
Key words: ovarian stimulation / aneuploidy / blastocyst / PGS