Granulocyte colony stimulating factor(G-CSF)

G-CSF, known initially as a blood growth factor, has important implications for non-blood cells such as endometrium cells and plays a direct role in endometrial growth. Few days before embryo transfer, a G-CSF intrauterine infusion for patients with thin endometrium RIF can improve clinical pregnancy rates.

Several studies have shown that G-CSF contributes to implantation and ovarian functions, as well as endometrial thickness and endometrial pathophysiology improvement.